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| Abstract: | A series of novel naphthyridine derivatives 3 and 4 was prepared from substituted pyridine 2 and ketones using ZnCl2 as catalyst under microwave irradiation conditions. All the compounds were evaluated for AChE inhibitory activity and promising compounds 3d, 3e, 4b, and 4g was identified. Representative compounds 3d and 3e were found to show insignificant THLE-2 liver cell viability/toxicity. The binding mode between X-ray crystal structure of human AChE and compounds was studied using molecular docking method and fitness scores were found to be in good correlation with the activity data. |
| Description: | Med Chem Res (2012) 21:1785–1795 DOI 10.1007/s00044-011-9695-0 |
| URI: | http://dyuthi.cusat.ac.in/purl/4162 |
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| A facile and si ... ivity, and molecular m.pdf | (1.024Mb) |
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